--- !oddb.org,2003/ODDB::CyP450SubstrateConnection 
oid: 705
cyp450: !oddb.org,2003/ODDB::CyP450 
  cyp_id: 2D6
  inhibitors: 
  - !oddb.org,2003/ODDB::CyP450InhibitorConnection 
    oid: 81
    category: ""
    links: []

    substance: !oddb.org,2003/ODDB::Substance 
      oid: 6361
      descriptions: !oddb.org,2003/ODDB::SimpleLanguage::Descriptions 
        fr: "Chlorph\xC3\xA9namine"
        de: Chlorphenamin
        lt: Chlorphenaminum
        en: Chlorphenamine
      synonyms: 
      - Chlorpheniraminum
      - Chlorpheniramin
      - Chlorpheniramine
      - "Chlorph\xC3\xA9niramine"
      swissmedic_code: 
    auc_factor: "1"
  - !oddb.org,2003/ODDB::CyP450InhibitorConnection 
    oid: 104
    category: 
    links: []

    substance: !oddb.org,2003/ODDB::Substance 
      oid: 5953
      descriptions: !oddb.org,2003/ODDB::SimpleLanguage::Descriptions 
        de: Sertindol
        lt: Sertindolum
        en: Sertindole
      synonyms: []

      swissmedic_code: 
    auc_factor: 
  - !oddb.org,2003/ODDB::CyP450InhibitorConnection 
    oid: 103
    category: ""
    links: 
    - !oddb.org,2003/ODDB::Interaction::AbstractLink 
      info: Cytochrome P450-mediated metabolism of the HIV-1 protease inhibitor ritonavir (ABT-538) in human liver microsomes.
      href: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Retrieve&list_uids=8613951&dopt=Abstract
      text: J Pharmacol Exp Ther 1996;277(1):423-431
    substance: !oddb.org,2003/ODDB::Substance 
      oid: 5851
      descriptions: !oddb.org,2003/ODDB::SimpleLanguage::Descriptions 
        lt: Ritonavirum
        en: Ritonavir
      synonyms: []

      swissmedic_code: 
    auc_factor: "1"
  - !oddb.org,2003/ODDB::CyP450InhibitorConnection 
    oid: 98
    category: ""
    links: 
    - !oddb.org,2003/ODDB::Interaction::AbstractLink 
      info: "Apparent mechanism-based inhibition of human CYP2D6 in vitro by paroxetine: comparison with fluoxetine and quinidine."
      href: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12584155&dopt=Abstract
      text: Drug Metab Dispos. 2003 Mar;31(3):289-93.
    - !oddb.org,2003/ODDB::Interaction::AbstractLink 
      info: CYP2D6 genotype, antidepressant use, and tamoxifen metabolism during adjuvant breast cancer treatment.
      href: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15632378&dopt=Abstract
      text: J Natl Cancer Inst. 2005 Jan 5;97(1):30-9.
    - !oddb.org,2003/ODDB::Interaction::AbstractLink 
      info: Active tamoxifen metabolite plasma concentrations after coadministration of tamoxifen and the selective serotonin reuptake inhibitor paroxetine.
      href: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=14652237&dopt=Abstract
      text: J Natl Cancer Inst. 2003 Dec 3;95(23):1758-64.
    - !oddb.org,2003/ODDB::Interaction::AbstractLink 
      info: Inhibition by paroxetine of desipramine metabolism in extensive but not in poor metabolizers of sparteine.
      href: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8513845&dopt=Abstract
      text: Eur J Clin Pharmacol 44:349-355, 1993.
    - !oddb.org,2003/ODDB::Interaction::AbstractLink 
      info: Plasma concentrations of clozapine and its major metabolites during combined treatment with paroxetine or sertraline.
      href: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11147928&dopt=Abstract
      text: Pharmacopsychiatry. 2000 Nov;33(6):213-7.
    - !oddb.org,2003/ODDB::Interaction::AbstractLink 
      info: "CYP2D6 inhibition by selective serotonin reuptake inhibitors: analysis of achievable steady-state plasma concentrations and the effect of ultrarapid metabolism at CYP2D6."
      href: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12173784&dopt=Abstract
      text: Pharmacotherapy. 2002 Aug;22(8):1001-6.
    substance: !oddb.org,2003/ODDB::Substance 
      oid: 6155
      descriptions: !oddb.org,2003/ODDB::SimpleLanguage::Descriptions 
        fr: Paroxetine
        de: Paroxetin
        lt: Paroxetinum
        en: Paroxetine
      synonyms: []

      swissmedic_code: 
    auc_factor: "5"
  - !oddb.org,2003/ODDB::CyP450InhibitorConnection 
    oid: 1421954
    category: ""
    links: 
    - !oddb.org,2003/ODDB::Interaction::AbstractLink 
      info: Akathisia with combined use of midodrine and promethazine.
      href: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16670408&query_hl=3&itool=pubmed_DocSum
      text: JAMA. 2006 May 3;295(17):2000-1.
    substance: !oddb.org,2003/ODDB::Substance 
      oid: 6912
      descriptions: !oddb.org,2003/ODDB::SimpleLanguage::Descriptions 
        de: Midodrin
        fr: Midodrine
        lt: Midodrinum
        en: Midodrine
      synonyms: []

      swissmedic_code: 
    auc_factor: "1"
  - !oddb.org,2003/ODDB::CyP450InhibitorConnection 
    oid: 1421969
    category: ""
    links: []

    substance: !oddb.org,2003/ODDB::Substance 
      oid: 1227735
      descriptions: !oddb.org,2003/ODDB::SimpleLanguage::Descriptions 
        en: Histamine H1 Receptor Antagonists
      synonyms: []

      swissmedic_code: 
    auc_factor: "1"
  - !oddb.org,2003/ODDB::CyP450InhibitorConnection 
    oid: 106
    category: ""
    links: 
    - !oddb.org,2003/ODDB::Interaction::AbstractLink 
      info: Potent inhibition of cytochrome P-450 2D6-mediated dextromethorphan O-demethylation by terbinafine.
      href: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10383919&dopt=Abstract
      text: Drug Metab Dispos. 1999 Jul;27(7):770-5.
    substance: !oddb.org,2003/ODDB::Substance 
      oid: 5971
      descriptions: !oddb.org,2003/ODDB::SimpleLanguage::Descriptions 
        de: Terbinafin
        lt: Terbinafinum
        en: Terbinafine
      synonyms: []

      swissmedic_code: 
    auc_factor: "2"
  - !oddb.org,2003/ODDB::CyP450InhibitorConnection 
    oid: 90
    category: 
    links: []

    substance: !oddb.org,2003/ODDB::Substance 
      oid: 5837
      descriptions: !oddb.org,2003/ODDB::SimpleLanguage::Descriptions 
        de: Fluvoxamin
        fr: Fluvoxamin
        lt: Fluvoxamin
        en: Fluvoxamine
      synonyms: []

      swissmedic_code: 
    auc_factor: