• -Valproat Atazanavir/RitonavirCarbamazepinEthiny AripiprazolBupropionFelbamatGabapentin
• - lestradiol/Levonorgestrel-Kombination LacosamidLevetiracetamLithiumOlanzapin
• - Lopinavir/RitonavirPhenobarbitalPhenyt OxcarbazepinParacetamolPerampanelPrega
• - oinPrimidonRifampicin balinTopiramatZonisamid
• +Valproat Atazanavir/Ritonavir Carbamazepin Aripiprazol Bupropion Felbamat
• + Ethinylestradiol/Levonorgestrel-Kombin Gabapentin Lacosamid Levetiracetam
• + ation Lopinavir/Ritonavir Lithium Olanzapin Oxcarbazepin
• + Phenobarbital Phenytoin Primidon Paracetamol Perampanel Pregabalin
• + Rifampicin Topiramat Zonisamid
• -mtdavon
• -SuizidgedankenVorber 19/1212 (1.6%)1/1212 15/1054 (1.4%)0/1054 1.08 (0.54; 2.18)inf 0.860.500.560.50
• -eitende HandlungenSu (0.1%)7/1212 (0.0%)4/1054 (0.05; inf)1.51
• -izidversucheVollende (0.6%)2/1212 (0.2%) (0.4%)0/1054 (0.0%) (0.43; 5.98)inf
• -te Suizide (0.21; inf)
• +mt davon
• +Suizidgedanken 19/1212 (1.6%) 15/1054 (1.4%) 1.08 (0.54; 2.18) 0.86 0.50 0.56 0.50
• +Vorbereitende 1/1212 (0.1%) 0/1054 (0.0%) inf (0.05; inf)
• +Handlungen Suizidver 7/1212 (0.6%) 4/1054 (0.4%) 1.51 (0.43; 5.98)
• +suche Vollendete 2/1212 (0.2%) 0/1054 (0.0%) inf (0.21; inf)
• +Suizide
• - Antiepileptikaabsolu Prozent Placeboabsolut Prozent OR
• - t
• + Antiepileptika Prozent Placebo absolut Prozent OR
• + absolut
• -mtdavon
• -SuizidgedankenVorber 67/278633/2786330/27 0.24%0.01%0.11%0.01% 29/160291/160298/160 0.18%<0.01%0.04%0.00 1.331.732.16-
• -eitende HandlungenSu 8634/27863 290/16029 %
• -izidversucheVollende
• -te Suizide
• +mt davon
• +Suizidgedanken 67/27863 3/27863 0.24% 0.01% 0.11% 29/16029 1/16029 0.18% <0.01% 0.04% 1.33 1.73 2.16 -
• +Vorbereitende 30/27863 4/27863 0.01% 8/16029 0/16029 0.00%
• +Handlungen Suizidver
• +suche Vollendete
• +Suizide
• -Behandlungszeitraum PlaceboN = 119 LithiumN = 120 LamotriginN = 165 PlaceboN = 69 LithiumN = 44 LamotriginN = 58
• +Behandlungszeitraum Placebo N = 119 Lithium N = 120 Lamotrigin N = 165 Placebo N = 69 Lithium N = 44 Lamotrigin N = 58
• -Behandlungszeitraum PlaceboN = 119 LithiumN = 120 LamotriginN = 165 PlaceboN = 69 LithiumN = 44 LamotriginN = 58
• +Behandlungszeitraum Placebo N = 119 Lithium N = 120 Lamotrigin N = 165 Placebo N = 69 Lithium N = 44 Lamotrigin N = 58
• -Behandlungszeitraum PlaceboN = 119 LithiumN = 120 LamotriginN = 165 PlaceboN = 69 LithiumN=44 LamotriginN = 58
• +Behandlungszeitraum Placebo N = 119 Lithium N = 120 Lamotrigin N = 165 Placebo N = 69 Lithium N=44 Lamotrigin N = 58