• -Analysesatz Celecoxib100–200 Ibuprofen600–800 mg Naproxen375–500 mg Gesamt
• - mg, 2x/Tag 3x/Tag 2x/Tag
• +Analysesatz Celecoxib 100–200 Ibuprofen 600–800 Naproxen 375–500 mg Gesamt
• + mg, 2x/Tag mg 3x/Tag 2x/Tag
• -hmerN/A – not
• +hmer N/A – not
• -HR (95% CI)P value 0.93 (0.76, 1.13)0.4 0.86 (0.70, 1.04)0.1 1.08(0.89, 1.31)
• - 5 2
• +HR (95% CI) P value 0.93 (0.76, 1.13) 0.86 (0.70, 1.04) 1.08 (0.89, 1.31)
• + 0.45 0.12
• - Celecoxib100–200 mg Ibuprofen600–800 mg Naproxen375–500 mg
• - 2x/Tag 3x/Tag 2x/Tag
• + Celecoxib 100–200 Ibuprofen 600–800 Naproxen 375–500 mg
• + mg 2x/Tag mg 3x/Tag 2x/Tag
• -HR (95% CI)P value 0.97 (0.83-1.12)0.64 0.87 (0.75-1.01)0.06
• +HR (95% CI) P value 0.97 (0.83-1.12) 0.87 (0.75-1.01)
• + 0.64 0.06
• -HR (95% CI)P value 0.71 (0.54-0.93)0.01 0.65 (0.50-0.85)0.00
• - 2
• +HR (95% CI) P value 0.71 (0.54-0.93) 0.65 (0.50-0.85)
• + 0.01 0.002
• -HR (95% CI)P value 0.79 (0.56-1.12)0.19 0.61 (0.44-0.85)0.00
• - 4
• +HR (95% CI) P value 0.79 (0.56-1.12) 0.61 (0.44-0.85)
• + 0.19 0.004
• -HR (95% CI)P value 0.80 (0.63-1.00)0.05 0.92 (0.73-1.17)0.49
• - 2
• +HR (95% CI) P value 0.80 (0.63-1.00) 0.92 (0.73-1.17)
• + 0.052 0.49
• - eventsCSGE: Composite of serious
• -gastrointestinal events.
• + events CSGE: Composite of
• +serious gastrointestinal events.