This group comprises X-ray, MRI and Ultrasound contrast media. The X-ray contrast media are subdivided into iodinated and non-iodinated compounds, and are further classified according to water solubility, osmolarity and nephrotropic/hepatotropic properties. High osmolar substances correspond mainly to ionic substances, except from ioxaglic acid, which is classified together with the non-ionic substances. MRI contrast media are subdivided according to magnetic properties.

The microspheres may contain various ingredients. E.g. perflutren suspension in microspheres of phospholipids is classfied in V08DA04.
Perflenapent covers structural isomers of dodecafluoropentane i.e. perflisopent.