Enemas and rectal foams for treatment of e.g. ulcerative colitis are classified here. Oral corticosteroids with poor systemic availability (i.e. regarded as locally acting) solely indicated for the treatment of intestinal inflammatory diseases are also classified here.
Sublingual formulations of budesonide for the treatment of eosinophilic esophagitis and oral formulations of budesonide for the treatment of primary immunoglobulin A nephropathy are classified in this group.